Kinda like Mr Data I am on an older comp using XP and it just has been rock solid with Reaper for over 4 years. I am one of those, "if it ain't broke, don't fix it" kind of guys. I dread the day this baby gives up and I have to start over (but I do back everything up like crazy). That said, I tried to help a buddy with his Vista system and just had nothing but struggles. Perhaps there are others out there using Vista that can give advise based on their experience. As far as multi in, right now I am using a Delta 1010LT soundcard which gives me 8 channels of simo recording using an old analog mixer, and 3 different outputs for mixing which is really handy. Again, it works great, but it seems like not very many new computers come with open PCI slots (all are PCI express), so I imagine when the time comes for a new comp, I will start over with firewire which also means a new interface (oh well, it's only money). Not sure this is helpful, but just sharing for what it is worth.