1. yes, you can use the SB for midi. just buy a gameport/midi adapter for $20 at any music store. 2. no, it will be in sync. 3. yes, PTLE has a midi sequencer built in. if you want to hear your rom sounds, just set the output of your midi track to the wavetable midi port just like any other sequencer. 4. no, but you can use the SB wavetable. preferrably, you would use soundfonts instead of the wavetable sounds. 5. yes, its a full blown midi sequencer as well as a fantastic audio recording/mixing app.